SEATTLE--(BUSINESS WIRE)--Blaze Bioscience, the Tumor Paint Company®, a biotechnology company focused on guided cancer therapy, today announced open enrollment for the first clinical study of Tumor Paint BLZ-100 in children with brain cancer. The study, entitled “A Phase 1 dose-escalation and expansion study of BLZ-100 in pediatric subjects with primary central nervous system tumors,” will be conducted at Seattle Children’s Hospital under the direction of principal investigator Dr. Sarah Leary.
The Phase 1 trial, which is operating under the company’s open Investigational New Drug (IND) application with the U.S. Food and Drug Administration (FDA), will enroll up to twenty-seven (27) patients, from infants through young adults under age 30 who have been diagnosed with a brain tumor, and will evaluate the safety and imaging characteristics of BLZ-100.
BLZ-100 is the first product candidate from Blaze’s Tumor Paint platform and consists of an Optide (optimized peptide), which binds and internalizes into cancer cells, and a fluorescent dye, which emits light in the near-infrared range. Tumor Paint products are designed to provide real-time, high-resolution intraoperative visualization of cancer cells, enabling more precise, complete resection of cancer throughout surgery. Preclinical utility of Tumor Paint technology has been demonstrated in a wide range of cancer types, including brain, lung, breast, prostate, and colorectal. BLZ-100 is currently in multiple Phase 1 proof-of-concept clinical studies to evaluate the safety and imaging characteristics of BLZ-100 in solid tumor cancers.
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