SEATTLE--(BUSINESS WIRE)--Blaze Bioscience, the Tumor Paint Company®, a biotechnology company focused on guided cancer therapy, today announced open enrollment for a clinical study of Tumor Paint BLZ-100 in soft tissue sarcoma. The study, titled “A Phase 1 study of BLZ-100 administered by intravenous injection in subjects with soft tissue sarcoma undergoing surgery,” is supported by a Small Business Innovation Research (SBIR) Phase II contract awarded to the company by the National Cancer Institute (NCI)1 following the successful completion of a Phase I SBIR contract. This is the fourth Phase 1 clinical trial under the company’s open Investigational New Drug (IND) application with the U.S. Food and Drug Administration (FDA). The study will be conducted at Cedars-Sinai Medical Center in Los Angeles under the direction of Principal Investigator Charles Forscher, M.D., and will enroll up to twenty-one (21) patients.
Soft tissue sarcoma is a rare disease with a high unmet need and, according to NCI, approximately 11,900 new cases of soft tissue sarcoma will be diagnosed in 2015 in the U.S. Surgery remains the principle mode of therapy for soft tissue sarcoma, and successful surgery—achieving complete resection with negative tumor margins—reduces the chance of recurrence and the need for more treatment, such as radiation or repeat surgery. “Sarcoma is an often aggressive cancer that disproportionally affects children and young adults. Improvements to treatment, including surgical intervention, are greatly needed,” said Dennis Miller, Ph.D., Blaze Bioscience’s Senior Vice President of Development and Principal Investigator on the NCI contract. “This clinical study of BLZ-100 will add to our growing understanding of the potential broad utility of BLZ-100 in cancer surgery and provide further insight to the timing of BLZ-100 dosing relative to tumor surgery.”
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