MILPITAS, Calif., Sept. 23, 2015 /PRNewswire/ -- Protagonist Therapeutics, Inc., a company developing novel, orally stable peptide therapeutics for gastrointestinal (GI) diseases and disorders, today announced receipt of a Phase 1 Small Business Innovation Research (SBIR) Grant from the National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health. This award, Number R43DK104445, will support research aimed at optimizing lead molecules in Protagonist's second pipeline program, focused on orally stable peptide antagonists of the interleukin-23 (IL-23) receptor as potential treatments for inflammatory bowel diseases (IBD).
Protagonist's research has shown that orally stable, GI-restricted drugs discovered using the company's peptide technology platform are efficacious in rodent models of colitis. This award furthers the company's efforts to translate these proof-of-concept early research findings into a potential human therapeutic that is orally delivered at high drug levels in diseased intestinal tissue with very limited drug concentrations in systemic circulation.
"We are very pleased to receive this grant, which provides further validation of the strong potential offered by our technology platform for the creation of novel, orally stable peptide drugs. Through this award, the reviewers also recognize the considerable benefit which could be provided for the treatment of inflammatory bowel disease through a first-in-class therapeutic targeting the IL-23/Th17 pathway," said David Y. Liu, Ph.D., Protagonist Chief Scientific Officer. "The SBIR program at NIH plays a vital role in helping companies develop new technology and products that serve important U.S. health care needs."
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