BASKING RIDGE, N.J., Dec. 01, 2015 (GLOBE NEWSWIRE) -- Caladrius Biosciences, Inc. (“Caladrius” or the “Company”) (NASDAQ:CLBS), a cell therapy company combining an industry-leading external development and manufacturing provider with a development pipeline in immunotherapy, announces today the publication of two-year results from a Phase 1 clinical study of an autologous Regulatory T cell (Treg) immunotherapy for type 1 diabetes (T1D). The study investigated a product that is the forerunner of the Company’s CLBS03 product candidate for recent-onset T1D.
The publication, entitled “Type 1 diabetes immunotherapy using polyclonal regulatory T cells,” was published in Science Translational Medicine and authored by a team led by Jeffrey A. Bluestone, PhD, Professor at the Diabetes Center, University of California San Francisco, and a member of the Company’s Type 1 Diabetes Scientific Advisory Board.
The Phase 1 open-label, uncontrolled dose-escalating study was conducted at the University of California, San Francisco and Yale University and provided evidence for safety and tolerability of autologous expanded polyclonal Treg cell therapy in fourteen adults with recent-onset T1D. In the Phase 1 trial, subjects received ex vivo-expanded Tregs, ranging in dose from 5 million to 2.6 billion cells. The study found that autologous Tregs can be expanded and were well tolerated in patients with recent-onset T1D. Additionally, the Tregs retained their T cell receptor diversity and demonstrated enhanced functional activity.
Read more: http://globenewswire.com/news-release/2015/12/01/791891/0/en/Caladrius-Announces-Publication-of-Two-Year-Results-From-Phase-1-Trial-of-Type-1-Diabetes-Product-Candidate-in-Science-Translational-Medicine.html