Source: Novo Nordisk & reported by http://www.prnewswire.com/
ORLANDO, Fla., May 27, 2016 /PRNewswire/ -- Findings from a phase 3a clinical trial for semaglutide, an investigational glucagon-like peptide-1 (GLP-1) analogue, demonstrated that treatment with semaglutide, administered once-weekly, significantly improved glycemic control compared to insulin glargine U100 in adults with type 2 diabetes. Results from the SUSTAIN 4 trial were presented today at the American Association of Clinical Endocrinologists 25th Annual Scientific and Clinical Congress (AACE) in Orlando, Fla.
The 30-week SUSTAIN 4 trial showed that, from a mean baseline HbA1c of 8.2%, adults with type 2 diabetes receiving metformin with or without sulfonylurea, achieved statistically significant and superior improvements in HbA1c reductions of 1.2% and 1.6% when treated with 0.5 mg and 1.0 mg semaglutide, respectively, vs a 0.8% reduction with insulin glargine U100 (p<0.0001 for both).1 End of trial mean dose of insulin glargine U100 was 29 IU/day. "Type 2 diabetes is a complex disease and many patients on insulin are still uncontrolled," said Vanita Aroda, SUSTAIN 4 investigator and physician investigator at the MedStar Health Research Institute, Hyattsville, Md. "The results of SUSTAIN 4 are encouraging, as once-weekly semaglutide demonstrated superior glycemic control compared to insulin glargine U100 in people that generally had a relatively long duration of type 2 diabetes." Read more: http://www.prnewswire.com/news-releases/semaglutide-demonstrated-superior-glycemic-control-vs-insulin-glargine-u100-in-adults-with-type-2-diabetes-300276365.html