Angew Chem Int Ed Engl. 2016 Apr 18;55(17):5124-34. doi: 10.1002/anie.201508428. Epub 2016 Mar 16.
Peptide-decorated dendrimers (PDDs) are a class of spherical, regular, branched polymers that are modified by peptides covalently attached to their surface. PDDs have been used as protein mimetics, novel biomaterials, and in a wide range of biomedical applications. Since their design and development in the late eighties, poly-l-lysine has been a preferred core structure for PDDs. However, numerous recent innovations in polymer synthesis and ligation chemistry have re-energized the field and led to the emergence of well-defined peptide dendrimers with more diverse core structures and functions. This Minireview highlights the development of PDDs driven by significantly improved ligation chemistry incorporating structurally well-defined peptides and the emerging use of PDDs in imaging and drug development.
Wan J1, Alewood PF2.
- 1Institute of Molecular Bioscience, The University of Queensland, 306 Carmody Road, St Lucia, QLD 4072, Australia.
- 2Institute of Molecular Bioscience, The University of Queensland, 306 Carmody Road, St Lucia, QLD 4072, Australia. firstname.lastname@example.org.