Senior Vice President, Peptides, IPSEN
Advances in Non-Invasive Routes of Administration of Peptides: Focus on Successful Oral Technologies Progressing in the Clinic
Most of large molecules like proteins and peptides are administered chronically through the parenteral route, sometimes for long periods of treatment. For this reason, there is a real interest in developing and bringing to the market formulations that can be administered through a non-invasive route, either transdermal, oral, buccal, or nasal and pulmonary. The purpose is really to focus on the patient and improve compliance, treatment adherence and patient comfort. Many progresses have been made in the recent years in the field of non-invasive routes of administration, most of them significantly progressing in the Clinic. As peptides generally show a very low ability to cross the membranes, one of the main challenges is the development of new technologies that improve permeability of these molecules across the epithelial membranes. The purpose of this talk is to review and discuss the key oral peptide delivery technologies significantly progressing in the Clinic, as well as the key challenges related to the very low oral bioavailability and the safety/efficacy profile.