Associate Professor, The Scripps Research Institute - Florida
Cysteine-Mediated Redox Signaling: Chemical Tools for Biology Discovery
The exploration of thiol-based redox regulation and signaling offers a grand challenge for achieving a molecular-level understanding of its unique role in physiology and pathology. Redox biology also represents a frontier for developing new therapeutics for cancer, neurodegenerative, and metabolic diseases. We are developing novel small-molecule probes as a way to identify and study the underlying chemistry that governs thiol-based redox signaling. This talk will present our latest results in the discovery and understanding of reactive oxygen species as emerging new chemical signals and their influence on protein function vis-à-vis the oxidative post-translational modification of pivotal cysteine residues.