Peptide based drug discovery and research is increasingly at the forefront in addressing new therapeutic challenges due to their high target selectivity and potency with low toxicity. Automated solid phase peptide synthesis (SPPS) increases reliability, efficiency, and crude purity for peptides in drug discovery and development. For example, introducing heat (>50°C) in the SPPS of linear peptides has shown improved results with shorter coupling cycles and higher crude purity.
The MK2 inhibitor, MMI-0100, is a cell penetrating peptide that is currently undergoing clinical trials for fibrotic and inflammatory lung disease [1,2]. Previously, the optimized synthesis of a MMI-0100 analog (AAVGLQRALAKARAQRAAARAY) was done using an automated system with a four-day method that consisted of double and triple couplings with the highest purities around 50%. In this study, different conditions and methods for the synthesis of the MMI-0100 analog using parallel synthesis were assessed. The full synthesis was completed in less than 24 h with improved crude purities.
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 "Moerae Matrix - Scientific Platform," Moerae Matrix, 2017. [Online]. Available: http://moeraematrix.com/. [Accessed March 2017].