Research Professor, Chemistry, Center for Developmental Therapuetics, Northwestern University
Peptides enabling extended intravitreal drug delivery as nano-particle conjugates
Short peptides containing 2-4 L-Arg residues were linked to condensed dextran nanoparticles yielding < 100nm carriers with zeta potential from +3 to+9 mV, diffusing very slowly in vitreous humor by IVIS, with promise to to enable controlled intraocular drug delivery.
BS-Chemistry City College of CUNY, PhD Biochemistry Brandeis University, Jane Coffin Childs Postdoc fellow Harvard, U of Texas Med School faculty 1978-84. Abbott Laboratories Drug Discovery 1984-2011, Outstanding Researcher of 2003 Abbott Labs. Res. Prof. Northwestern University Ctr Dev Therapeut 2013-2018. Current funding National Eye Institute. Coauthor 94 refereed pubs., inventor 12 US patents on peptides and/or angiogenesis. 12 Invited reviews or book chapters. Major interest-peptide therapeutics.