Proceedings - Boulder Peptide Foundation

BPS 2016

Comparison of select peptide time-extension technologies in the context of a GIP/GLP-1-based dual-agonist peptide

Adam Mezo

Sr. Research Advisor, Group Leader, Eli Lilly and Company

ABSTRACT

Peptides possess enormous potential to contribute to the current standard of care across many therapeutic areas. By virtue of their inherently short plasma residence time, it is advantageous to identify robust strategies to extend their time-of-action in circulation to lessen the burden of frequent injections. GIP/GLP-1-based dual agonists represent a novel approach to treat diabetes, but such peptides still require protraction in circulation to reduce the burden of frequent injections. In this study, a GIP/GLP-1-based dual-agonist peptide was derivatized with iodoacetamide and conjugated to thiol-bearing time-extension moieties. Four different time-extension technologies were evaluated and compared: native human albumin, XTEN (3 sizes), heparosan (3 sizes), and hydroxyl ethyl starch (3 sizes). The presentation will discuss the in vitro activity of the peptide analogs against the GLP1-R and GIP-R, as well as their pharmacokinetic and pharmacodynamic characteristics in preclinical in vivo models.

BIO

Adam Mezo, PhD. is currently a Sr. Research Advisor and leads a team of discovery peptide and protein chemists at Eli Lilly and Company in search of next-generation therapeutics primarily in the fields of endocrinology and neurology. Prior to this role, he spent 12 years at Biogen Idec and Syntonix Pharmaceuticals in a variety of roles, most recently as a Director, Molecular Discovery, where he led a diverse team of chemists, biochemists, and molecular biologists in the discovery and development of peptide and protein therapeutics in the fields of hemophilia and immunology. He performed postdoctoral work at the Massachusetts Institute of Technology in the field of peptide chemistry, received a Ph.D. in organic chemistry from the University of British Columbia in 1999 and a B.S. from Queenâ€™s University (Kingston, Canada) in 1993.

Oral Presentations in Scientific Sessions

The session topics for Scientific Program are Peptides in the Clinic, Drug Delivery, Chemistry of Complex Peptides, Spotlight on Discovery, and Peptide Showcase. Abstracts may be submitted via the Apply to Present page on the website. Submissions will be reviewed by the Scientific Advisory Board on a monthly basis and the speaker will be notified of a decision.

Presentation length: Format is 25-30 minutes slide presentation with 5-10 minutes for Q&A, with the exception of Peptide Showcase talks which are 10 minute slide presentations with 5 minutes for Q&A. Please confirm with your session chair to confirm the exact presentation length.

Invited Speakers: Speakers are requested to supply their presentation details 30 days after receiving an invitation to present.

Program Book Deadline: Final abstract and title must be provided no later than September 1st. No changes to the program are possible after this date.

Presentation Format: Oral presenters please provide your presentation slides to the A/V table on the day of your presentation.

Lodging: All speakers are requested to reserve their own room. Discount rates at the conference hotel are available until August 16th.

Registration: All speakers, excluding sponsored presentation speakers, receive a complimentary registration upon approval of the abstract.

Peptide Showcase Description

The Peptide Showcase is an opportunity for an individual or company to “showcase” new ideas, technology and pipeline assets. Priority shall be given to presentations from biotech and startup companies. Service providers and vendors are not eligible. Speakers in the session receive a complimentary event registration.

Posters

Posters can be presented on any topic relevant to peptides including original research, innovative products and technologies.

Eligibility- Any attendee (from academia, industry, biotech or vendor/sponsor) can present a poster. The presentation must contain original scientific thinking. To submit a poster go to the Submit a Poster link from the meeting menu. All submissions are reviewed on a rolling basis and will be notified of approval. September 1st is the last day to submit a poster abstract. Approved posters are published on the BPF website.

A 30 ” x 40″ board shall be provided with thumb tacks. Board will be on an easel and can be rotated for either landscape or portrait formats. Once you apply for a poster, you will get email confirmation that your poster was accepted. The poster session and number assignments will be emailed one week before the Symposium.

Poster boards shall be available for display from 8am to 8pm the day of your assigned poster session. See the program agenda for the poster session schedule.

Public Release

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