Proceedings - Boulder Peptide Foundation

BPS 2017

ORBIT Peptide Display – High Throughout Selection of Peptides with Biological Function

Alex Batchelor

Alex, Orbit Discovery Ltd

ABSTRACT

Peptides are highly active biological molecules in vivo and as their stability and bioavailability is improved they offer greater potential as therapeutic drugs. Peptide library screening incorporating enhancements and non-linear structures is increasingly important to identify molecules with activity on a diverse range of therapeutic targets.

Existing screening approaches include phage display, yeast display, ribosomal and mRNA displays. The in vitro display methods struggle to express peptides at the numbers required for detection of low affinity interactions while the in vivo methods cannot incorporate non-natural amino acids or avoid interference from the autologous proteins of the host.

The ORBIT display technology multiplexes a library of translated peptides and their encoding DNA on the surface of beads. It has the positive attributes of in vitro display combined with the sensitivity of in vivo methods. It can be adapted for cell surface screening, enabling measurement of cell surface binding and functional response. We will show data from three target screens in three therapeutic areas: GP120 binding protein (infectious disease), mutant RAS (oncology) and T-cell epitopes (inflammation). Peptides that inhibit virus infection, bind mutants and have specific sequence to T cell receptor were identified.

The tolerance of beads to chemical and physical treatment expands the application of ORBIT to cyclic peptides and the incorporation of non-natural amino acids. The bead display approach has many potential applications for probing biological systems and for drug lead development.

BIO

Alex is CEO of Orbit Discovery with more than 20 years’ experience of sales, marketing and business development in the life science research and drug discovery markets in Europe, US and Asia.

He is an experienced bridge between technical and commercial groups, having started his career in research for the UK Ministry of Defence before moving into industry where he has managed staged R&D processes, implemented IP strategies and launched many successful products and services at companies including Lonza and Genalyte.

Alex holds a BA in Pure and Applied Biology from Brasenose College, Oxford.

Oral Presentations in Scientific Sessions

The session topics for Scientific Program are Peptides in the Clinic, Drug Delivery, Chemistry of Complex Peptides, Spotlight on Discovery, and Peptide Showcase. Abstracts may be submitted via the Apply to Present page on the website. Submissions will be reviewed by the Scientific Advisory Board on a monthly basis and the speaker will be notified of a decision.

Presentation length: Format is 25-30 minutes slide presentation with 5-10 minutes for Q&A, with the exception of Peptide Showcase talks which are 10 minute slide presentations with 5 minutes for Q&A. Please confirm with your session chair to confirm the exact presentation length.

Invited Speakers: Speakers are requested to supply their presentation details 30 days after receiving an invitation to present.

Program Book Deadline: Final abstract and title must be provided no later than September 1st. No changes to the program are possible after this date.

Presentation Format: Oral presenters please provide your presentation slides to the A/V table on the day of your presentation.

Lodging: All speakers are requested to reserve their own room. Discount rates at the conference hotel are available until August 16th.

Registration: All speakers, excluding sponsored presentation speakers, receive a complimentary registration upon approval of the abstract.

Peptide Showcase Description

The Peptide Showcase is an opportunity for an individual or company to “showcase” new ideas, technology and pipeline assets. Priority shall be given to presentations from biotech and startup companies. Service providers and vendors are not eligible. Speakers in the session receive a complimentary event registration.

Posters

Posters can be presented on any topic relevant to peptides including original research, innovative products and technologies.

Eligibility- Any attendee (from academia, industry, biotech or vendor/sponsor) can present a poster. The presentation must contain original scientific thinking. To submit a poster go to the Submit a Poster link from the meeting menu. All submissions are reviewed on a rolling basis and will be notified of approval. September 1st is the last day to submit a poster abstract. Approved posters are published on the BPF website.

A 30 ” x 40″ board shall be provided with thumb tacks. Board will be on an easel and can be rotated for either landscape or portrait formats. Once you apply for a poster, you will get email confirmation that your poster was accepted. The poster session and number assignments will be emailed one week before the Symposium.

Poster boards shall be available for display from 8am to 8pm the day of your assigned poster session. See the program agenda for the poster session schedule.

Public Release

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