BPS 2017

Prospects of PASylation® for the design of protein and peptide therapeutics with extended half-life and enhanced action

Uli Binder

Chief Technology Officer, XL-protein GmbH

ABSTRACT

PASylation® technology comprises the conjugation – via genetic fusion or chemical coupling – of peptides, proteins and small molecule drugs, with natively disordered biosynthetic polypeptides made of the small L-amino acids Pro, Ala and/or Ser. Such proline/alanine-rich sequences (PAS) are highly soluble in physiological solution and stably adopt random coil conformation. This results in an expanded hydrodynamic volume, leading to retarded kidney filtration and drastically prolonged pharmacokinetics in vivo. The intrinsically uncharged PAS polypeptides do not interfere with the pharmacological activity of the drug component and show high stability in plasma as well as no immunogenicity. Furthermore, PAS sequences undergo quick degradation and metabolization after cellular uptake, thus avoiding side effects such as organ accumulation or vacuolation typically seen for several PEGylated products. PASylation is compatible with bacterial, yeast as well as mammalian expression systems and allows a cheap, one-step production of the PAS-fusion protein/peptide without the need of costly chemical modification steps. This presentation will focus on fundamental concepts of PASylation and will highlight recent advances in preclinical applications.

BIO

Uli Binder is Co-founder of XL-protein GmbH and acts as Chief Technology Officer of the company since it’s since its inception in 2009. He studied Molecular Biotechnology and accomplished his Ph.D. studies at the Technical University of Munich in the field of protein engineering.

Information for BPS Presenters

The Boulder Peptide Foundation was established to further the science and knowledge of peptide technology to develop novel therapeutics, biomaterials, medical diagnostics and other beneficial uses for mankind. As part of this goal we run several programs to support career advancement, seminars and educational events. Join us on our mission to expand the applications of peptide science.

Information for BPS Presenters

The purpose of the Boulder Peptide Symposium is to encourage sharing of information related to peptide therapeutic development with an emphasis on the technical, scientific and regulatory aspects of the pharmaceutical development. Presentations that demonstrate original thinking or share experiences from case studies in product development shall receive priority over others.

The Boulder Peptide Symposium offers multiple opportunities for participants to present.

Oral Presentations in Scientific Sessions

The session topics for Scientific Program are Peptides in the Clinic, Drug Delivery, Chemistry of Complex Peptides, Spotlight on Discovery, and Peptide Showcase. Abstracts may be submitted via the Apply to Present page on the website. Submissions will be reviewed by the Scientific Advisory Board on a monthly basis and the speaker will be notified of a decision.

Presentation length: Format is 25-30 minutes slide presentation with 5-10 minutes for Q&A, with the exception of Peptide Showcase talks which are 10 minute slide presentations with 5 minutes for Q&A. Please confirm with your session chair to confirm the exact presentation length.

Invited Speakers: Speakers are requested to supply their presentation details 30 days after receiving an invitation to present.

Program Book Deadline: Final abstract and title must be provided no later than September 1st. No changes to the program are possible after this date.

Presentation Format: Oral presenters please provide your presentation slides to the A/V table on the day of your presentation.

Lodging: All speakers are requested to reserve their own room. Discount rates at the conference hotel are available until August 16th.

Registration: All speakers, excluding sponsored presentation speakers, receive a complimentary registration upon approval of the abstract.

Peptide Showcase Description

The Peptide Showcase is an opportunity for an individual or company to “showcase” new ideas, technology and pipeline assets. Priority shall be given to presentations from biotech and startup companies. Service providers and vendors are not eligible. Speakers in the session receive a complimentary event registration.

Posters

Posters can be presented on any topic relevant to peptides including original research, innovative products and technologies.

Eligibility- Any attendee (from academia, industry, biotech or vendor/sponsor) can present a poster. The presentation must contain original scientific thinking. To submit a poster go to the Submit a Poster link from the meeting menu. All submissions are reviewed on a rolling basis and will be notified of approval. September 1st is the last day to submit a poster abstract. Approved posters are published on the BPF website.

A 30 ” x 40″ board shall be provided with thumb tacks. Board will be on an easel and can be rotated for either landscape or portrait formats. Once you apply for a poster, you will get email confirmation that your poster was accepted. The poster session and number assignments will be emailed one week before the Symposium.

Poster boards shall be available for display from 8am to 8pm the day of your assigned poster session. See the program agenda for the poster session schedule.

Public Release

Every presentation at the Boulder Peptide Symposium is automatically recorded. Speakers are required to give consent for sharing of the presentation video with the peptide community.

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