Proceedings - Boulder Peptide Foundation

BPS 2023

Translating B-cell epitope peptide cancer vaccines into clinical immunotherapies and combinations in Immuno-Oncology.

Pravin Kaumaya

Professor of Medicine and Director Vaccine Research, Indiana University

ABSTRACT

Current targeted therapies face many obstacles in the clinic. These include the rapid development of resistance, high toxicity rates, on or off-target effects, and weak efficacy. The promise of peptides will invigorate drug innovation and discovery, and challenge the ingenuity of researchers to develop cancer cures and future therapies that are safe and non-toxic. Our novel targeted immunotherapy approach overcomes these obstacles and holds the promise of making a major leap in the clinical treatment of cancer.
My lecture will address the Promise Of B-cell Epitope Vaccine Immunotherapies: Tackling Challenges In Combinatorial Checkpoint Inhibitor Vaccines PD-L1 and CTLA-4 B-cell epitope vaccines. The following topics will be presented
– Vaccine Strategies with Checkpoint Inhibitors (PD-1, PD-L1, CTLA-4, TIGIT & LAG3)
– Combination Immunotherapy HER-2 with PD-1, PD-L1 and CTLA-4 vaccines
– Syngeneic mice models (CT26, CT26/HER-2; MC38, MC38/HER2; D2F2,D2F2/E2; 4T1;B16
– Additive/synergistic safe anti-tumor activity
– The future of cancer vaccines and the fundamentals of new vaccine discovery and development

BIO

BIOGRAPHY
Dr Kaumaya is Professor of Medicine in the Department of Ob/Gyn at the OSU Wexner Medical Center and the James Comprehensive Cancer Center. Dr Kaumaya is internationally recognized as an expert in the fields of vaccine research with emphasis on peptide vaccines for cancer. His work over 3 decades in developing B-cell epitope-based cancer vaccines is a paradigm shift in the immune-oncology landscape. Dr. Kaumaya is an elected fellow of the American Association for the Advancement of Science (AAAS), and he was elected as the treasurer of the American Peptide Society since 2009. He has lectured worldwide and has published over 130 peer-reviewed articles in major scientific journals. He is an inventor on several issued and pending patents for peptide cancer vaccines and immune-therapeutic technologies. He conducts translational research from bench to the clinic with the goal of designing and developing new combination immunotherapies and immunologic strategies for cancer treatment and prevention. Dr Kaumaya’s laboratory has recently developed a PD-1-Vaxx B-cell peptide cancer vaccine and has also developed vaccines for PD-L1, CTLA-4, TIGIT, TIM3 and LAG-3 which will be developed as combination immunotherapy. This work demonstrates a growing immune-oncology platform for developing combination immunotherapy, widely considered the next frontier in treating cancer and the potential to deliver many breakthroughs in cancer care.

Oral Presentations in Scientific Sessions

The session topics for Scientific Program are Peptides in the Clinic, Drug Delivery, Chemistry of Complex Peptides, Spotlight on Discovery, and Peptide Showcase. Abstracts may be submitted via the Apply to Present page on the website. Submissions will be reviewed by the Scientific Advisory Board on a monthly basis and the speaker will be notified of a decision.

Presentation length: Format is 25-30 minutes slide presentation with 5-10 minutes for Q&A, with the exception of Peptide Showcase talks which are 10 minute slide presentations with 5 minutes for Q&A. Please confirm with your session chair to confirm the exact presentation length.

Invited Speakers: Speakers are requested to supply their presentation details 30 days after receiving an invitation to present.

Program Book Deadline: Final abstract and title must be provided no later than September 1st. No changes to the program are possible after this date.

Presentation Format: Oral presenters please provide your presentation slides to the A/V table on the day of your presentation.

Lodging: All speakers are requested to reserve their own room. Discount rates at the conference hotel are available until August 16th.

Registration: All speakers, excluding sponsored presentation speakers, receive a complimentary registration upon approval of the abstract.

Peptide Showcase Description

The Peptide Showcase is an opportunity for an individual or company to “showcase” new ideas, technology and pipeline assets. Priority shall be given to presentations from biotech and startup companies. Service providers and vendors are not eligible. Speakers in the session receive a complimentary event registration.

Posters

Posters can be presented on any topic relevant to peptides including original research, innovative products and technologies.

Eligibility- Any attendee (from academia, industry, biotech or vendor/sponsor) can present a poster. The presentation must contain original scientific thinking. To submit a poster go to the Submit a Poster link from the meeting menu. All submissions are reviewed on a rolling basis and will be notified of approval. September 1st is the last day to submit a poster abstract. Approved posters are published on the BPF website.

A 30 ” x 40″ board shall be provided with thumb tacks. Board will be on an easel and can be rotated for either landscape or portrait formats. Once you apply for a poster, you will get email confirmation that your poster was accepted. The poster session and number assignments will be emailed one week before the Symposium.

Poster boards shall be available for display from 8am to 8pm the day of your assigned poster session. See the program agenda for the poster session schedule.

Public Release

Every presentation at the Boulder Peptide Symposium is automatically recorded. Speakers are required to give consent for sharing of the presentation video with the peptide community.