BPS 2025

Development of Heteromultivalent Peptide-decorated Nanoparticles for Hemorrhage Control

Christa Pawlowski

COO, EVP Research & Development, Haima Therapeutics LLC

ABSTRACT

Effective hemorrhage control requires rapid platelet activity at the site of injury, yet donor platelets face supply and storage limitations. SynthoPlate is a synthetic nanoparticle decorated with a rationally designed, heteromultivalent set of short peptides that mimic essential platelet functions. These include peptides for binding exposed collagen and von Willebrand factor and binding to endogenous platelets via fibrinogen-mimetic peptides. This modular, peptide-driven design enables site-specific adhesion and amplification of clot formation while minimizing off-target clotting risks. Preclinical studies show that SynthoPlate reduces bleeding time and blood loss with a favorable safety profile. Lyophilization and scalable manufacturing further support its translation as a first-in-class, peptide-based, donor-independent hemostatic therapy.

BIO

Dr. Christa Pawlowski has over 15 years of drug discovery and development experience across therapeutic indications including cardiovascular disorders, inflammatory diseases, immunology, and oncology. Dr. Pawlowski is COO and EVP of R&D at Haima Therapeutics, a company focused on the development of peptide-decorated, platelet-inspired nanotechnologies for the treatment of hemorrhage and other blood-related ailments. She previously served as Director of Operations at BioMotiv, a biotech accelerator, managing two start-ups: SapVax (developing adjuvanted peptide immunotherapies for cancer) and Allinaire Therapeutics (developing biologics for cardiopulmonary diseases). She received her PhD in Biomedical Engineering from Case Western Reserve University.

Information for BPS Presenters

The Boulder Peptide Foundation was established to further the science and knowledge of peptide technology to develop novel therapeutics, biomaterials, medical diagnostics and other beneficial uses for mankind. As part of this goal we run several programs to support career advancement, seminars and educational events. Join us on our mission to expand the applications of peptide science.

Information for BPS Presenters

The purpose of the Boulder Peptide Symposium is to encourage sharing of information related to peptide therapeutic development with an emphasis on the technical, scientific and regulatory aspects of the pharmaceutical development. Presentations that demonstrate original thinking or share experiences from case studies in product development shall receive priority over others.

The Boulder Peptide Symposium offers multiple opportunities for participants to present.

Oral Presentations in Scientific Sessions

The session topics for Scientific Program are Peptides in the Clinic, Drug Delivery, Chemistry of Complex Peptides, Spotlight on Discovery, and Peptide Showcase. Abstracts may be submitted via the Apply to Present page on the website. Submissions will be reviewed by the Scientific Advisory Board on a monthly basis and the speaker will be notified of a decision.

Presentation length: Format is 25-30 minutes slide presentation with 5-10 minutes for Q&A, with the exception of Peptide Showcase talks which are 10 minute slide presentations with 5 minutes for Q&A. Please confirm with your session chair to confirm the exact presentation length.

Invited Speakers: Speakers are requested to supply their presentation details 30 days after receiving an invitation to present.

Program Book Deadline: Final abstract and title must be provided no later than September 1st. No changes to the program are possible after this date.

Presentation Format: Oral presenters please provide your presentation slides to the A/V table on the day of your presentation.

Lodging: All speakers are requested to reserve their own room. Discount rates at the conference hotel are available until August 16th.

Registration: All speakers, excluding sponsored presentation speakers, receive a complimentary registration upon approval of the abstract.

Peptide Showcase Description

The Peptide Showcase is an opportunity for an individual or company to “showcase” new ideas, technology and pipeline assets. Priority shall be given to presentations from biotech and startup companies. Service providers and vendors are not eligible. Speakers in the session receive a complimentary event registration.

Posters

Posters can be presented on any topic relevant to peptides including original research, innovative products and technologies.

Eligibility- Any attendee (from academia, industry, biotech or vendor/sponsor) can present a poster. The presentation must contain original scientific thinking. To submit a poster go to the Submit a Poster link from the meeting menu. All submissions are reviewed on a rolling basis and will be notified of approval. September 1st is the last day to submit a poster abstract. Approved posters are published on the BPF website.

A 30 ” x 40″ board shall be provided with thumb tacks. Board will be on an easel and can be rotated for either landscape or portrait formats. Once you apply for a poster, you will get email confirmation that your poster was accepted. The poster session and number assignments will be emailed one week before the Symposium.

Poster boards shall be available for display from 8am to 8pm the day of your assigned poster session. See the program agenda for the poster session schedule.

Public Release

Every presentation at the Boulder Peptide Symposium is automatically recorded. Speakers are required to give consent for sharing of the presentation video with the peptide community.

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