Peptides are ideal drug candidates due to their inherent high potency, low toxicity, and their ability to effect a broad range of targets . With several high revenue peptide drugs on the market and a full pipeline of potential candidates , the demand for a highly robust and effective synthetic method is of great importance .
Currently, peptide synthesis research and production both face similar challenges – a sluggish and wasteful workflow in desperate need for optimization. The typical conventional optimization steps usually take a shotgun approach: screen resins, screen different reagent excesses, screen activators, etc. This synthetic process necessitates tens or hundreds of reactions, all of which can often take weeks or months to complete while requiring a great deal of time, money, and resources.
To address the needs of the market, new cGMP methodology has been developed utilizing automation and microwave assisted heating. This work details mechanistic-based, innovative improvements to the chemical methodology of solid phase peptide synthesis, application of these improvements to high-throughput SPPS for personalized medicine via peptide vaccines [4,5] and large scale peptide production with cGMP considerations.
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