Professor, Universiy of KwaZulu-Natal
Cyclic Peptides from Nature to the Laboratory
Herein, we will review our current research devoted to the synthesis of natural cyclic peptides (pipecolidepsin, baringolin, teixobactin,…) as well as the design and synthesis of cyclic peptides with improved properties. In this regard, we will discuss the strategies carried out in our laboratory for improving the potency and the stability of peptides. In addition to homodetic cyclizations, we will show as common techniques used in conventional organic chemistry can be applied to peptides for that purposes. Thus, Pd catalyzed coupling reactions allows the efficient preparation of linked, constrained and stapled peptides through C-H Pd activation processes.
Fernando Albericio is Research Professor at the University of KwaZulu-Natal in South Africa and Full Professor at the University of Barcelona. His major research interests cover practically all aspects of peptide synthesis: new reactions, building blocks, coupling reagents, solid phase supports, protecting groups, and linkers, as well as synthesis of peptides and small molecules with therapeutic activities. Recently, his group is introducing the Green Solid-Phase Peptide Synthesis. This year, he has received the “Murray Goodman Scientific Excellence & Mentorship Award” from the American Peptide Society.