Head of Discovery, Novo Nordisk
Oral Delivery of a Derivatized Glucagon-Like Peptide-1 Receptor Agonist
• Peptides such as insulin and glucagon-like peptide-1 (GLP-1) receptor agonists are used in the treatment of type 2 diabetes.
• The inherent physicochemical properties of these peptides (high molecular weight, enzymatically labile, hydrophilicity, and low permeability) have hampered attempts to deliver peptides via the oral route and necessitated that they be administered by injection.
• Recently, oral semaglutide, a GLP-1 analog, coformulated with the absorption enhancer sodium N-[8-(2-hydroxybenzoyl) aminocaprylate] (SNAC) in a tablet has been developed.
• This presentation will provide an overview of how this coformulation provides unique, site-directed release and absorption in the stomach and effectively surmounts inherent challenges relating to solubility, molecular size, and proteolytic lability to achieve therapeutically relevant plasma exposure of semaglutide.
Dr. Stephen T. Buckley is Head of Department in the Discovery ADME department at Novo Nordisk A/S, Denmark. He holds a degree in Pharmacy from Trinity College Dublin (Ireland), and a Ph.D in Biopharmaceutics and Cell Physiology from the same university. During this time, he also worked as a Visiting Fellow at the University of Southern California (USA). Prior to his current position at Novo Nordisk A/S, Dr. Buckley was a Postdoctoral Research Fellow at the University of Southern Denmark (Denmark).
He is the recipient of honours and awards from the American Association of Pharmaceutical Scientists (AAPS) and the Scandinavian and German Physiological Societies. Dr. Buckley’s work is focused on understanding the various processes underlying the absorption and distribution of proteins and peptides via employment of in vitro cellular permeability models, ex vivo tissue models and binding assays. In addition to his leadership responsibilities, he is responsible at Novo Nordisk for a team tasked with identifying and evaluating novel drug delivery technologies.
He is (co-) author of 25+ articles in peer-reviewed journals (including Science and Science Translational Medicine), 1 book chapter and 30+ abstracts, and has been invited to give numerous presentations at research institutions, international conferences and workshops.