A recent phase 1/2 study under review at the Nature Portfolio journal and posted to the Research Square* preprint server demonstrated that a peptide-centered severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) T-cell activator, CoVac-1, was efficient in B-cell deficient people.
Background
The SARS-CoV-2-induced coronavirus disease 2019 (COVID-19) pandemic prompted the invention of numerous vaccinations that safeguard billions of humans from the disease's severe course, primarily through the generation of humoral or antibody-triggered immunity. T-cell immunity is critical for controlling SARS-CoV-2 infection, especially in individuals who cannot generate a humoral immune response to a prophylactic vaccination or natural infection. Individuals with inherited B-cell deficiency and cancer patients with treatment- or disease-linked B cell reduction fall into this category. T cells are crucial for COVID-19 outcomes and SARS-CoV-2 immunity maintenance in addition to B cell-driven humoral immunity.
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