Regiostereomers and diastereomers can be separated with Phenyl or biphenyl-bonded stationary phases. The poster compares the different separation patterns achieved by Phenyl (attached via C6 chains) and biphenyl (in two different bonded ligand densities) with the conventional C18 separation. The new, different separation patterns open a dazzling variety of ways to achieve separation in your large-scale API purification processes. Alternative separation modes may be the answer to many tough peptide purification challenges! The “PIE IN THE SKY” has been made a reality!