Through continuous innovation in the field of solid-phase peptide synthesis (SPPS), a novel bromine-functionalized polystyrene/ DVB resin was designed to enhance the synthesis of C-terminal acid peptides, achieving high yields and low impurities.
Currently, the industry relies on two widely accepted resins for synthesizing acid peptides: the Wang resin and the 2-CTC resin. Each of these resins has its own well-documented advantages and limitations, making the selection process crucial for specific applications.
The case studies presented herein demonstrate the effectiveness of the MBH-Br (4-Methylbenzhydryl bromide) resin in addressing the challenges associated with the synthesis of acid peptides showing low DKP and high stability to peptide elongation. These studies highlight the resin’s ability to facilitate the production of both protected and unprotected acid peptides, showcasing its potential to improve efficiency and purity in peptide synthesis and consequently supporting the peptide manufacturers in achieving better output.
