BPS 2024 Proceedings
MEIENHOFER AWARD PRESENTATION
Fernando Albericio
Professor
University of KwaZulu-Natal, University of Barcelona
Solid-Phase Peptide Synthesis as a Puzzle of Resins, Protecting Groups, Coupling Reagents in a Proper Solvent
Peptide Showcase
Brief 15 minute presentations from companies developing peptide therapeutics and related technologies. This rapid and compressed format is designed for quick introduction between symposium participants to new technologies, and companies. Each presentation is structured to highlight the value of the technology or therapeutic being offered and the business strategy.
Alexander Pisarchik
Director of Protein Engineering
Alcamena Stem Cell therapeutics, LLC
Novel Method of Peptide Discovery: case of IL-6 Antagonist
Ishita Shah
CEO
Matrubials, Inc.
Selective milk-inspired peptides for treatment of bacterial vaginosis
Jari Willems
Chemical Scientist
Endoprotease Services BV
C-terminal functionalization of recombinantly expressed proteins
Hans Melo
CEO
Menten AI, Inc.
Menten AI: A Generative AI Platform for Design And Optimization of Cyclic Peptides
Karsten Eastman
CEO, Post-doctoral Scholar
Sethera, University of Utah
Controllable and Scalable Synthesis of Polymacrocyclic and Multi-Chain Peptides Using Radical-Mediated Enzymatic Methods
Fa Liu
Chief Scientific Officer
Full-Life Technologies
Radionuclide-Peptide Conjugate (RDC), a rising modality for cancer treatment
Jeff Posakony
Director of Translational Chemistry
AltPep Corporation
Synthetic Alpha-sheet Peptides for Treatment of Amyloid Diseases
Rick Ewing
VP, Head of Chemistry
Rapafusyn
RapaGlues and RapaTags – A Bridge between Macrocyclic Peptides and Molecular Glues for Interrogating Hard to Drug Targets
Peptides in the Clinic
Updates on clinical development of peptide therapeutics.
Mridula Dogra
Sr. Advisor-ADME Project Leadership
Eli Lilly and Company
Metabolism and disposition of 14C-retatrutide in preclinical species and humans
Masahiro Kojima
Researcher
Chugai Pharmaceutical Co., Ltd.
Development of Orally Bioavailable Peptides Targeting an Intra-cellular Protein: From a Hit to a Clinical KRAS Inhibitor
John Mumm
President & CEO
Deka Biosciences Inc
Enhancing function and controlling TCE mediated CRS with DK210 Diakines™
Abi Vainstein Haras
Chief Medical Officer
Sapience Therapeutics, Inc.
Clinical Update on ST101, a Peptide Antagonist of C/EBP-beta in Development for Glioblastoma
Drug Delivery
Novel approaches to peptide drug delivery including devices, molecular engineering, conjugation, and formulation technologies.
Markus Muttenthaler
Professor in Medicinal and Biological Chemistry
The University of Queensland
New opportunities for gut-specific oral peptide drug development
Christine Beeton
Professor
Baylor College of Medicine
Bioengineering probiotic bacteria for the oral delivery of peptide therapeutics
Samir Mitragotri
Professor
Harvard University
Ionic Liquids for Peptide Delivery
Thomas Von Erlach
CSO
Vivtex
Oral delivery of peptide therapeutics through whole GI tissue high-throughput screening
David Guay
VP Innovation and Technology
Feldan Therapeutics
Amphiphilic Shuttle Peptides Enable PMO Delivery to Basal Cell Carcinoma and Airway Epithelia
Spotlight on Discovery
This year’s Spotlight on Discovery is focused on peptide use in alcohol & drug addiction research.
Jane Aldrich
Professor
University of Florida
Opportunities and Challenges in Developing Macrocyclic Peptides as Potential Treatments for Substance Abuse
Jean Bidlack
Professor of Pharmacology and Physiology
University of Rochester School of Medicine and Dentistry
The pharmacological properties of opioid peptides and alkaloids are dependent on which Gα subunit is coupled to the opioid receptor
Joseph Schacht
Associate Professor
University of Colorado School of Medicine
Exploring GLP-1 Agonists as Candidate Medications for Alcohol Use Disorder
Chemistry of Complex Peptides
Alicia Engelbrecht
Post Doc Process Science, Project Lead
Boehringer Ingelheim RCV GmbH & Co KG.
Biopharmaceutical Manufacturing of Boehringer Ingelheims Next Generation Peptides
Lenka Žáková
Scientist
Institute of Organic Chemistry and Biochemistry of the CAS
Investigating Hormone Functions Using Insulin and IGF Analogues
Bach-Ngan Wetzel
Postdoctoral Researcher
Numaferm GmbH
Revolutionizing Peptide Production: Introducing Numacut TEV Protease
Michael Kopach
Associate Vice President
Eli Lilly and Company
Development of a Three-Fragment Hybrid SPPS/LPPS Synthesis for Retatrutide
Maciej Walczak
Associate Professor
University of Colorado
Precision Chemistry: Tools for Targeted Peptide and Protein Modification
Workshops and Panels
Panel Discussion: Harnessing the Strength of Diversity in Clinical Trials
This panel on diversity in clinical trials explored the vital role that diverse populations play in advancing medical research and improving health outcomes. Experts discussed the benefits of diverse trials, such as improved drug efficacy across different populations and better safety profiles alongside strategies for overcoming barriers to participation, ensuring inclusive recruitment practices, and fostering trust within underrepresented communities. The session highlighted real-world examples and provided actionable steps to make clinical trials more equitable and representative.
Beyond Pharma Panel Discussion
This panel discussion looked at the use of peptides outside of the traditional pharmaceutical landscape. This provided an opportunity to understand, discuss, challenges and opportunities and how they compare with human pharmaceutical applications.
Preclinical Development Discussion: The “Black Box” between Med Chem and Clinical
A discussion with pharma leaders on the roadmap for early development with Tox, ADME, CMC and Phase 1 clinical design. Topics include Toxicity program for peptides, how to pick clinical dose, and preclinical to clinical translation. Panelists brought their experiences and discussed lessons learned in short presentations and a moderated roundtable.
Sponsored Presentations
Product and capability presentation from our sponsors
Stefan Eissler
Vice President of Peptide Manufacturing Upstream
Bachem
Synthetic Peptide Manufacturing: Options for the Upstream Process
John Phipps
Senior Director of Business Development
CPC Scientific
Synthesis of Highly Constrained Double- and Triple-Stapled Peptide Macrocycles
Charles Chase
VP Technical Business Development
Asymchem
Fragment Banking: A Strategy for Rapid Convergent Synthesis of Peptides
Hanna Radzey
Team Leader
Almac Group
Applications of experimental design in process validation of peptide manufacturing processes
Chloe Mitchell
Field Application Scientist
Gyros Protein Technologies
Navigating through advanced and greener synthesis and purification technology to prepare for the new era of peptide therapeutics
Yvonne Angell
Executive Director, Discovery Chemistry Project Managment
WuXi TIDES
Mastering and Accelerating Peptide Conjugates: Unveiling Success Strategies