Source: http://globenewswire.com/
TEMPE, Ariz., Oct. 14, 2015 (GLOBE NEWSWIRE) -- Capstone Therapeutics, Inc. (OTCQB:CAPS) ("the Company") and its (60% owned) joint venture affiliate, LipimetiX Development, Inc. ("JV"), announced today the allowance of U.S. Patent application number 12/675,089 for the use of apolipoprotein E mimetic peptides to decrease plasma glucose in patients with diabetes or insulin resistance. In multiple animal models AEM-28, the parent peptide in the JV's Chimeric Apolipoprotein E Mimetic Peptide (CHAMP) platform, increases insulin and glucose sensitivity, decreases plasma insulin and glucose and decreases weight gain in diet induced models of type 2 diabetes. The newly allowed patent expands the utility of the CHAMP technology beyond claims in previous JV patents for the treatment of diabetic dyslipidemia and vascular diseases.
"Macrophage infiltration of white adipose tissue in obesity contributes to a chronic inflammatory state resulting in altered cytokine secretion by the fat cells. The cytokine-created cross-talk between the inflamed adipose tissue, pancreas and liver results in altered metabolism, contributing to insulin resistance, elevated glucose and type 2 diabetes," according to Dennis Goldberg, Ph.D., President of LipimetiX. "Our data indicate that the CHAMPs help normalize lipid metabolism, modulate the macrophage phenotype and decrease inflammation in the adipose tissue. The decrease in weight gain in the diet induced obese mice occurred despite comparable caloric intake during the study. These biologic activities result in statistically significant beneficial effects on plasma glucose and plasma insulin in validated preclinical models."
Read more: http://globenewswire.com/news-release/2015/10/14/776035/10152400/en/Capstone-Therapeutics-Announces-Allowance-of-U-S-Patent-for-Treatment-of-Diabetes-With-Apo-E-Mimetic-Peptides.html