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TORONTO, June 08, 2020 (GLOBE NEWSWIRE) -- Arch Biopartners Inc. (“Arch” or the “Company”) (TSX Venture: ARCH and OTCQB: ACHFF), a clinical stage company developing new drug candidates for treating organ damage caused by inflammation, today announced it has submitted an Investigational New Drug (IND) Application to the U.S. Food and Drug Administration (FDA) for its lead drug Metablok (LSALT peptide) to conduct a Phase II trial to prevent acute organ inflammation and injury experienced by patients with COVID-19.

The submission of the IND application was made by Arch following several weeks of review of the Company’s Phase II plans by the FDA under the Coronavirus Treatment Acceleration Program. Read More

• NGIO has previously developed Ii-Key-H1 peptides for vaccines against epitopes to 2009 Swine Flu and 2004 Bird Flu with positive Phase I clinical safety and immunologic data for Ii-Key-H1 peptide vaccine
• Ii-Key-H1 peptide sequence is 100% homologous in previous pandemic influenza threats
• Potential to launch Ii-Key-H1 peptide vaccine for emerging pandemic threat from G4 EA H1N1 swine flu
• Published reference: Honglei et al. Prevalent Eurasian Avian-like H1N1 Swine Influenza Virus with 2009 Pandemic Viral Genes Facilitating Human Infection. Proceedings of the National Academy of Sciences; June 2020. (See Link) https://www.pnas.org/content/early/2020/06/23/1921186117?referringSource=articleShare

MIRAMAR, Fla., July 02, 2020 (GLOBE NEWSWIRE) -- NuGenerex Immuno-Oncology today announced that the company is launching a vaccine development effort to address the new, emerging pandemic threat from a newly identified swine Read More

Enterome completes Series E financing round, with Takeda returning to provide funds to the biotech. Read More

LONDON, June 15, 2020 (GLOBE NEWSWIRE) -- Treos Bio Limited, a clinical stage biopharma company developing targeted peptide cancer immunotherapies, today said that it has developed and successfully tested in silico a preventive COVID-19 peptide vaccine and has transferred all rights, including pending patent applications, to a newly formed subsidiary, PepTC Vaccines Limited.

Treos developed this preventive vaccine product, PolyPEPI-SCoV-2, using its proprietary, computational vaccine design technology.

PepTC Vaccines’ PolyPEPI-SCoV-2 investigative vaccine is designed to elicit long-term T cell immunity in contrast to most of the vaccine candidates being developed with antibodies. It consists of 10 different, 30-amino acid long synthetic peptides. Read More

From Science Journal:

Abstract

Liver resident-memory CD8⁺ T cells (T_RM cells) can kill liver-stage Plasmodium-infected cells and prevent malaria, but simple vaccines for generating this important immune population are lacking. Here, we report the development of a fully synthetic self-adjuvanting glycolipid-peptide conjugate vaccine designed to efficiently induce liver T_RM cells. Upon cleavage in vivo, the glycolipid-peptide conjugate vaccine releases an MHC I–restricted peptide epitope (to stimulate Plasmodium-specific CD8⁺ T cells) and an adjuvant component, the NKT cell agonist α-galactosylceramide (α-GalCer). A single dose of this vaccine in mice induced substantial numbers of intrahepatic malaria-specific CD8⁺ T cells expressing canonical markers of liver T_RM cells (CD69, CXCR6, and CD101), and these cells could be further increased in number upon vaccine boosting. We show that modifications to the peptide, such as addition of proteasomal-cleavage sequences or epitope-flanking sequences, or the use of alternative conjugation methods to link the peptide to the glycolipid improved liver T_RM cell generation and led to the development of a vaccine able to induce sterile protection in C57BL/6 mice against Plasmodium berghei sporozoite challenge after a single dose. Furthermore, this vaccine induced endogenous liver T_RM cells that were long-lived (half-life of ~425 days) and were able to maintain >90% sterile protection to day 200. Our findings describe an ideal synthetic vaccine platform for generating large numbers of liver T_RM cells for effective control of liver-stage malaria and, potentially, a variety of other hepatotropic infections. Read More