Source: http://www.businesswire.com/
MONTREAL--(BUSINESS WIRE)--Angiochem, a biotechnology company developing drugs that are uniquely capable of crossing the blood-brain barrier (BBB) announced positive clinical results with ANG1005, a novel paclitaxel-peptide drug conjugate, in breast cancer patients with leptomeningeal carcinomatosis (LC), a metastatic cancer that spreads rapidly to the membranes of the brain and spinal cord. Interim data from this ongoing Phase 2 study were presented at the 20th Annual Scientific Meeting of the Society for Neuro-Oncology (SNO) at San Antonio, Texas. Based on these results, Angiochem is developing a multi-study Phase 3 clinical program to evaluate ANG1005 in breast cancer patients with or without LC.
In a poster titled “ANG1005, a Novel Brain-penetrant Peptide-taxane Conjugate, for the Treatment of CNS Metastases from Breast Cancer,” Angiochem researchers and collaborators at Northwestern University and other clinical centers reported interim Phase 2 study results demonstrating that breast cancer patients with brain metastases treated with ANG1005, including a subset of patients with LC, achieved encouraging responses. Of the 21 heavily pre-treated patients with LC, 5 patients (24%) achieved a partial response (PR) and 11 patients (52%) had stable disease (SD) as best intracranial response. The Kaplan-Meier estimates of survival in patients with LC treated with ANG1005 predict a median survival (95% CI) of 38.4 weeks as compared to 4-6 weeks if left untreated or 12-24 weeks with conventional chemotherapy. In addition, ANG1005 demonstrated intracranial and extracranial antitumor activity in patients with various other subtypes of breast cancer including patients previously treated with paclitaxel. ANG1005 was shown to be generally safe and well-tolerated, and demonstrated an adverse event profile consistent with conventional taxane therapy at both dose levels studied (550mg/m2 and 600mg/m2).
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