Protagenic Therapeutics, Inc. (OTCQB:PTIX) announced today that experiments conducted at independent contract research organizations have demonstrated that PT00114, its novel drug candidate for the treatment of stress-related mental disorders, has rapid and long-lasting activity. These studies were conducted in established rodent models of anxiety and depression which have been predictive of responses in humans. PT00114 is a novel synthetic peptide closely related to TCAP, a naturally occurring brain peptide with deep evolutionary roots as an endogenous physiological mechanism for blunting the effects of stress.
Studies conducted at Charles River Laboratories in Finland have replicated and extended earlier observations that PT00114 significantly reduces stress in rodent models that are predictive of clinical efficacy. In these experiments PT00114 cut anxiety-related fear responses in half. Furthermore, these benefits were observed without sedation, reduction in locomotor activity, changes in feeding behavior, or evidence of dependency; all of which are important advantages over today’s anti-anxiety drugs. Among other unique properties of PT00114 is its rapid onset of action as compared to Prozac, Effexor, and other neurotransmitter reuptake inhibitors, which have many side effects and generally take several weeks to start working. Protagenic Therapeutics is advancing additional experiments to validate the effect of PT00114 for opioid addiction.
“We are excited to see the new data validating and extending our findings at the University of Toronto that TCAP, a natural brain peptide, can potentially be medicine for a number of serious psychiatric and addictive disorders,” said Dr. David Lovejoy, Professor of Cell and Systems Biology at the University of Toronto, and Chief Scientific Advisor of Protagenic Therapeutics.
“PT00114 counteracts the effects of Corticotropin Releasing Hormone, the body's 'master switch' coupling environmental stress to biochemical, metabolic, and behavioral disturbances. Unlike most side-effect-laden neuropsychiatric drugs, PT00114 acts through the body's natural control systems, restoring balance to the brain and reversing disordered behavior without untoward side effects,” said Robert B. Stein, M.D., Ph.D., Chair of the Protagenic Therapeutics Board of Directors Science Committee.
Protagenic Therapeutics is in discussions with government agencies for further testing of PT00114 in selected models of PTSD and for non-dilutive funding of up-coming clinical trials. Based on progress with PT00114, Protagenic Therapeutics is now entering into discussions with potential corporate partners.
About Protagenic Therapeutics, Inc.
Protagenic Therapeutics, Inc. (OTCQB:PTIX) is a pre-clinical biopharmaceutical company endeavoring to develop first-in-class neuro-active peptides into human therapeutics to treat anxiety, treatment-resistant depression, addiction, and other disorders. For more information, visit http://www.protagenic.com.