Source: Vaxon Biotech & reported by http://www.clinicalleader.com/
Vaxon Biotech, a biopharmaceutical company developing therapeutic cancer vaccines based on optimized cryptic peptides, recently announces the completion of enrollment for its phase 2b trial of Vx-001 in non-small-cell lung cancer (NSCLC). Vx-001 is a therapeutic cancer vaccine based on proprietary antigens known as optimized cryptic tumor peptides.
A total of 220 patients with metastatic NSCLC have now been enrolled in this phase 2b trial across 70 European trial centers. The primary endpoint is to assess the benefit of Vx-001 versus placebo on overall survival. Final trial results are expected in the fourth quarter of 2016.
An average of one in six patients were selected after meeting three criteria: expression of HLA-A2, TERT-expressing tumors and non-progression of cancer after first line chemotherapy. Over four months, participants received six doses of the Vx-001 vaccine or the placebo, then one dose every three months.
Vx-001 is the first vaccine to use optimized cryptic peptides and is the only such vaccine in development. Optimized cryptic peptides are universal tumor peptides that, while normally undetected by the immune system, have been modified to optimize their presentation to the immune system so as to induce a powerful anti-tumor immune response.
Read more: http://www.clinicalleader.com/doc/vaxon-biotech-completes-optimized-peptides-0001