BPS 2022 Proceedings

BPS 2022 Proceedings

Meienhofer Keynote Address

Stephen Kent

Professor
University of Chicago

Chemical Protein Synthesis – my Journey from SPPS to Chemical Ligation

Peptide Showcase

Brief 15 minute presentations from companies developing peptide therapeutics and related technologies. This rapid and compressed format is designed for quick introduction between symposium participants to new technologies, and companies. Each presentation is structured to highlight the value of the technology or therapeutic being offered and the business strategy.

Morten Lundh

Project Leader
Gubra

The streaMLine platform for accelerated clinical candidate identification

Massina Abderrahmane

Data Scientist
Iktos Inc

Representing, predicting, and generating simple and complex peptides

Dani Stoltzfus

Senior Director R & D Chemistry
NeuBase Therapeutics

Developing PNAs into Biotherapeutics

Ved Srivastava

Vice President, chemistry
Aktis Oncology

Realizing the curative power of alpha radiopharmaceuticals for mainstream cancer care

John McGee

Vice President and Scientific Co-Founder
FOG Pharmaceuticals Inc

Platforms for the Rapid Discovery of Helical Peptide Therapeutics

Sally Wang Liang

SVP of BD
PepLib

Beyond Binders: High-Throughput Peptide Screening for Functionally Active Hits

Lucas Siow

CEO and Co-Founder
ProteinQure Inc

Structure-driven exploration of non-canonical amino acid space for optimized peptide ligands

Patrick Salveson

VP Research and Discovery
Vilya

Computational macrocycle design with drug-like properties for targeted therapeutics

Dominik Sarma

Managing Director
Belyntic GmbH

Faster time-to-market with Peptide Easy Clean (PEC)

Spotlight on Discovery

Presentations of applied research from the academic labs.

Helena Safavi-Hemami

Associate Professor
University of Copenhagen, Denmark

Hormone-Like Peptides from Venomous Animals as Optimized Drug Leads for Disease

Christina Schroeder

Senior Fellow
Genentech

Recifin A, a Novel and Selective Allosteric Inhibitor of Tyrosyl-DNA Phosphodiesterase I with a Unique Disulfide-bond Topology

Ashlee Rowe

Assistant Professor
University of Oklahoma

Structure and Mechanism of a Novel Scorpion Peptide that Inhibits Nav1.8, a Voltage-Gated Sodium Channel Regulator of Pain Signal Transmission

Peptides in the Clinic

Updates on clinical development of peptide therapeutics.

Bernhard Fischer

CEO
APEPTICO

Clinical development of the solnatide peptide for the treatment of ARDS and COVID-19 during the corona pandemics. Identification of the 3D conformational ensemble of solnatide by crystallography and NMR

Johannes Koebberling

Senior Science Fellow
Bayer AG

Discovery and Early Development of Adrenomedullin Pegol (BAY 1097761) for the Treatment of ARDS – First Disclosure

Dieter Willbold

Director
Forschungszentrum Jülich

The All-D-Peptide PRI-002: Preclinical PoC and Clinical Phase Ib Data from Alzheimer’s Disease Patients

David Huang

CMO
Peptilogics

Engineered Peptide PLG0206 Overcomes Activity, Safety, and Pharmacokinetic Limitations of a Challenging Drug Class

Thomas Kruse

Senior Principal Scientist
Novo Nordisk

Preclinical and Clinical Development of Long-acting Amylin Agonists

Geoff Harris

Founder Ocelot Bio
Ocelot Bio

Designing a Mixed Agonist-Antagonist Peptide: A Case Study of OCE-205 in Advanced Liver Disease

Drug Delivery

Novel approaches to peptide drug delivery including devices, molecular engineering, conjugation, and formulation technologies

John Lewis

Professor
University of Alberta

Fusogenix Proteolipid Vehicles (PLVs) utilize fusion-associated transmembrane proteins to deliver DNA or RNA by direct fusion

Kevin McDonnell

VP Chemistry
Bicycle Therapeutics

Bicycles® are versatile vehicles for precision guided drug delivery

Ratmir Derda

Chief Operating Officer
48Hour Discovery

Novel, Peptide-Based Radiopharmaceuticals for the Treatment of Various Solid Tumors

Manuel Sanchez-Felix

Senior Fellow
Novartis

Patient-centric design for systemic peptide delivery: Trends in routes of administration and advancement in drug delivery technologies

Patrick Dougherty

Senior Scientist
Entrada Therapeutics

Development of Endosomal Escape Vehicles to Enhance the Intracellular Delivery of Oligonucleotides

Chemistry of Complex Peptides

Michal Avital-Shmilovici

Senior Scientist and Research Lead
SRI International

Mega-Throughput Screening of Large OBOC Non-Natural Peptide Libraries Using Fiber Optic Array Scanning Technology

Patrick Knerr

Senior Director & Site Head
Novo Nordisk Research Center Indianapolis

Discovery and Optimization of Long-Acting, Unimolecular Peptide Triple Agonists of the GLP-1, GIP, and Glucagon Receptors

Michael Stowell

Professor
University of Colorado – Boulder

Structural Complexities of Insulin Receptor Signaling

Les Miranda

Executive Director, R&D & CMC Operations
Amgen

GIPR antagonist antibodies conjugated to GLP-1 peptide are multispecific molecules that decrease weight in obese mice & monkeys

Hiroaki Suga

Professor
The University of Tokyo

Display and RaPID Selection of Pseudo-Natural Peptides and Products

Workshops and Panels

Pharma Circle Panel

Sandeep Somani

Principal Scientist
Janssen Research and Development

Jakob Fuhrmann

Principal Scientist
Genentech

Greg Adams

Associate Director Discovery Chemistry • Drug Design
Former Merck & Co. / Currently at Exscientia

Moderator – Chengzao Sun

Sr. Principal Scientist
Janssen, Inc.

Start-Up Workshop

Hiroaki Suga

Professor
The University of Tokyo

Cristina Rondinone

Founder/CEO
Pep2Tango Therapeutics Inc

Dave Garman

Chief Technology Officer
NoNO Inc.

Maria Soloveychik

CEO
SyntheX

Rami Hannoush

General Partner and Chief Scientific Officer
Mubadala Capital

Moderator – Ewa Lis

CEO
Koliber Biosciences Inc.

Sally Wang Liang

SVP of BD
PepLib

CEO Roundtable Discussion

Raymond De Vré

CEO
PolyPeptide Group

Thomas Meier

CEO
Bachem Holding AG

Mike Collins

President & CEO
CEM Corporation

Moderator – Trishul Shah

Director of Business Development
Polypeptide Group

Sponsored Presentations

Product and capability presentation from our sponsors

William Fang

VP, Head of New Modality Oligo/Peptide Business
STA Pharmaceutical

CMC Strategies and New Technology Applications for the Development of Peptide Drugs

Matteo Villain

Vice President CMC Development
Bachem

A New Linker for Peptide Bioconjugation – The Thiazine

Dale Thomas

Co-founder
Mytide Therapeutics

Cutting-Edge Chemistry: Harnessing AI-Based Robotics for Industry Changing, Fully Automated Peptide Production

Colton Quick

Product Specialist
Gyros Protein Technologies

From Small to Large Scale: Optimizing and Upscaling the Synthesis of Melanotan II (MT-II) – Melanocortin Receptor Agonist, on PurePep® Chorus and PurePep® Sonata+

Jonathan Loughrey

Physical Sciences Manager
Almac Group

The Advantages of Peptide Crystallization for Purification, Stability, and IP

Jonathan Collins

Vice President Business Development
CEM Corporation

Wash Free, One-Pot Fmoc Solid Phase Peptide Synthesis

Information for BPS Presenters

The Boulder Peptide Foundation was established to further the science and knowledge of peptide technology to develop novel therapeutics, biomaterials, medical diagnostics and other beneficial uses for mankind. As part of this goal we run several programs to support career advancement, seminars and educational events. Join us on our mission to expand the applications of peptide science.

Information for BPS Presenters

The purpose of the Boulder Peptide Symposium is to encourage sharing of information related to peptide therapeutic development with an emphasis on the technical, scientific and regulatory aspects of the pharmaceutical development. Presentations that demonstrate original thinking or share experiences from case studies in product development shall receive priority over others.

The Boulder Peptide Symposium offers multiple opportunities for participants to present.

Oral Presentations in Scientific Sessions

The session topics for Scientific Program are Peptides in the Clinic, Drug Delivery, Chemistry of Complex Peptides, Spotlight on Discovery, and Peptide Showcase. Abstracts may be submitted via the Apply to Present page on the website. Submissions will be reviewed by the Scientific Advisory Board on a monthly basis and the speaker will be notified of a decision.

Presentation length: Format is 25-30 minutes slide presentation with 5-10 minutes for Q&A, with the exception of Peptide Showcase talks which are 10 minute slide presentations with 5 minutes for Q&A. Please confirm with your session chair to confirm the exact presentation length.

Invited Speakers: Speakers are requested to supply their presentation details 30 days after receiving an invitation to present.

Program Book Deadline: Final abstract and title must be provided no later than September 1st. No changes to the program are possible after this date.

Presentation Format: Oral presenters please provide your presentation slides to the A/V table on the day of your presentation.

Lodging: All speakers are requested to reserve their own room. Discount rates at the conference hotel are available until August 16th.

Registration: All speakers, excluding sponsored presentation speakers, receive a complimentary registration upon approval of the abstract.

Peptide Showcase Description

The Peptide Showcase is an opportunity for an individual or company to “showcase” new ideas, technology and pipeline assets. Priority shall be given to presentations from biotech and startup companies. Service providers and vendors are not eligible. Speakers in the session receive a complimentary event registration.

Posters

Posters can be presented on any topic relevant to peptides including original research, innovative products and technologies.

Eligibility- Any attendee (from academia, industry, biotech or vendor/sponsor) can present a poster. The presentation must contain original scientific thinking. To submit a poster go to the Submit a Poster link from the meeting menu. All submissions are reviewed on a rolling basis and will be notified of approval. September 1st is the last day to submit a poster abstract. Approved posters are published on the BPF website.

A 30 ” x 40″ board shall be provided with thumb tacks. Board will be on an easel and can be rotated for either landscape or portrait formats. Once you apply for a poster, you will get email confirmation that your poster was accepted. The poster session and number assignments will be emailed one week before the Symposium.

Poster boards shall be available for display from 8am to 8pm the day of your assigned poster session. See the program agenda for the poster session schedule.

Public Release

Every presentation at the Boulder Peptide Symposium is automatically recorded. Speakers are required to give consent for sharing of the presentation video with the peptide community.