SAINT-GENIS-POUILLY, France, March 06, 2017 (GLOBE NEWSWIRE) -- Advanced Accelerator Applications S.A. (NASDAQ:AAAP) (“AAA” or the “Company”), an international specialist in Molecular Nuclear Medicine (MNM), today announced that quality of life findings from the pivotal NETTER-1 Phase III study investigating the treatment of Lutetium Lu 177 Dotatate in patients with somatostatin receptor positive midgut neuroendocrine tumors (midgut NETs) will be presented at the 14^th Annual Conference of the European Neuroendocrine Tumor Society (ENETS), March 8-10 in Barcelona, Spain.

The details of the presentations are as follows:

Abstract # 1676: NETTER-1 Phase III Trial: Recent Findings on Quality of Life in Patients with Midgut Neuroendocrine Tumors
Speaker: Jonathan Strosberg, MD, Associate Professor, Section Head, Neuroendocrine Tumor Program at Moffitt Cancer Center
Session Title: Clinical Abstracts (4B)
Session Date: March 9, 2017
Session Time: 14:15-14:25 Central European Time

About NETTER-1

NETTER-1 is the first Phase III multi-center, randomized, controlled trial evaluating Lutetium Lu 177 Dotatate in patients with inoperable, progressive, somatostatin receptor positive midgut NETs. 229 patients with Grade 1-2 metastatic midgut NETs (both functioning and not functioning) were randomized to receive Lutetium Lu 177 Dotatate 7.4 GBq every 8 weeks (x4 administrations), plus best supportive care (Octreotide LAR 30 mg for symptom control) versus Octreotide LAR 60 mg every 4 weeks. The primary endpoint was Progression Free Survival (PFS) per RECIST 1.1 criteria, with tumor response assessment performed by an independent blinded reading center every 12 weeks. Secondary endpoints included objective response rate, overall survival, safety, and health-related quality of life. Analysis of NETTER-1 PFS results showed the number of patients having disease progression or death was 23 in the Lutetium Lu 177 Dotatate arm and 68 in the Octreotide LAR 60 mg arm. Thus, the NETTER-1 study met its primary endpoint by demonstrating that treatment with Lutetium Lu 177 Dotatate was associated with a statistically significant and clinically meaningful risk reduction of 79% of disease progression or death versus Octreotide LAR 60 mg (hazard ratio 0.21, 95% CI: 0.13-0.33; p<0.0001).

About Lutetium Lu 177 Dotatate (Lutathera^®)

Lutetium Lu 177 Dotatate (Lutathera^®) is an investigational, Lu-177-labeled somatostatin analog peptide currently in development for the treatment of gastroenteropancreatic neuroendocrine tumors (GEP-NETs), including foregut, midgut, and hindgut neuroendocrine tumors in adults. Lutetium Lu 177 Dotatate belongs to an emerging form of treatments called Peptide Receptor Radionuclide Therapy (PRRT), which involves targeting neuroendocrine tumors with radiolabeled somatostatin analog peptides. This novel, investigational compound has received orphan drug designation from the European Medicines Agency (EMA) and the U.S. Food and Drug Administration (FDA). Currently, Lutetium Lu 177 Dotatate is administered on a compassionate use and named patient basis for the treatment of NETs and other tumors over-expressing somatostatin receptors in ten European countries and in the U.S. under an Expanded Access Program (EAP) for midgut NETs. New Drug Application and Marketing Authorization Application submissions to the FDA and EMA for Lutetium Lu 177 Dotatate are currently under review.

About Advanced Accelerator Applications

Advanced Accelerator Applications is an innovative radiopharmaceutical company that develops, produces and commercializes Molecular Nuclear Medicine products. AAA’s lead investigational therapeutic candidate, Lutetium Lu 177 Dotatate (Lutathera^®), is a novel MNM compound that AAA is currently developing for the treatment of Neuroendocrine Tumors, a significant unmet medical need. Founded in 2002, AAA has its headquarters in Saint-Genis-Pouilly, France. AAA currently has 22 production and R&D facilities able to manufacture both diagnostics and therapeutic MNM products, and has 500 employees in 13 countries (France, Italy, UK, Germany, Switzerland, Spain, Poland, Portugal, The Netherlands, Belgium, Israel, U.S. and Canada). AAA reported sales of €88.6 million in 2015 (+27% vs. 2014) and sales of €81.3 million for the first 9 months of 2016 (+23% vs. 9 months 2015). AAA is listed on the Nasdaq Global Select Market under the ticker “AAAP”. For more information, please visit: www.adacap.com.

Cautionary Statement Regarding Forward-Looking Statements

This press release may contain forward-looking statements. All statements, other than statements of historical facts, contained in this press release, including statements regarding the Company's strategy, future operations, future financial position, future revenues, projected costs, prospects, plans and objectives of management, are forward-looking statements. The words "anticipate," "believe," "estimate," "expect," "intend," "may," "plan," "predict," "project," "target," "potential," "will," "would," "could," "should," "continue," and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Forward-looking statements reflect the Company's current expectation regarding future events. These forward-looking statements involve risks and uncertainties that may cause actual results, events or developments to be materially different from any future results, events or developments expressed or implied by such forward-looking statements. Such factors include, but are not limited to, changing market conditions, the successful and timely completion of clinical studies, the timing of our submission of applications for regulatory approvals, EMA, FDA and other regulatory approvals for our product candidates, the occurrence of side effects or serious adverse events caused by or associated with our products and product candidates; our ability to procure adequate quantities of necessary supplies and raw materials for Lutetium Lu 177 Dotatate and other chemical compounds acceptable for use in our manufacturing processes from our suppliers; our ability to organize timely and safe delivery of our products or product candidates by third parties; any problems with the manufacture, quality or performance of our products or product candidates; the rate and degree of market acceptance and the clinical utility of Lutetium Lu 177 Dotatate and our other products or product candidates; our estimates regarding the market opportunity for Lutetium Lu 177 Dotatate, our other product candidates and our existing products; our anticipation that we will generate higher sales as we diversify our products; our ability to implement our growth strategy including expansion in the U.S.; our ability to sustain and create additional sales, marketing and distribution capabilities; our intellectual property and licensing position; legislation or regulation in countries where we sell our products that affect product pricing, taxation, reimbursement, access or distribution channels; regulatory actions or litigations; and general economic, political, demographic and business conditions in Europe, the U.S. and elsewhere. Except as required by applicable securities laws, we undertake no obligation to publicly update or revise any forward-looking statements, whether as a result of new information, future events or otherwise.

According to “Peptide Therapeutics Market: Global Industry Analysis and Opportunity Assessment, 2015-2025”, a latest report published by Future Market Insights (FMI), the global peptide therapeutics market is expected to increase at over 10% CAGR during 2015-2025.

According to the report, peptide therapeutics are gaining traction in the pharmaceutical industry, owing to their cost-effectiveness and efficacy in managing numerous disease indications.

Economic factors, such as government policies for start-up companies in emerging economies, increasing FDI, and increasing healthcare expenditure are also driving the use of peptides in therapeutics. Increasing prevalence of cardiovascular and metabolic disorders is expected to provide an impetus to R&D activities in using peptides as therapeutics.

Emergence of prominent pharmaceutical and biotech companies, high specificity of peptides leading, advanced and strong pipelines, and patent expiries are the other key factors driving the global peptide therapeutics market, according to FMI’s report.

“Revival of interest in peptides as potential drug candidates because of their low oral bioavailability has been a major factor fuelling growth of the global peptide therapeutics market. Lack of oral efficacy in peptide drug delivery has actually helped researchers to find innovative methods of peptide drug delivery. However, there is still low acceptance among end users; hence, creating awareness could open up opportunities in the market”, said FMI Analyst.

Request For Sample@ www.futuremarketinsights.com/reports/sample/rep-gb-1038

Peptide therapeutics are used for treating prostrate, breast, ovarian and pancreatic cancers. Peptides that are antagonists or agonists of specific receptors in oncology are increasingly being tested at the preclinical stages for their efficacy in cancer treatment. These increasing number of oncology studies indicate that there is an enormous cancer patient pool available globally, which is creating a larger niche for cancer application types in the global peptide therapeutic market.

Increasing commercialisation costs and low oral bioavailability of peptide drugs can impede the demand for peptides during the forecast market.

On the basis of disease indication, the global peptide therapeutics market is segmented into cancer, cardiovascular, central nervous systems, metabolic disorders, infection, hematological disorders, gastrointestinal disorders, dermatology, respiratory disorders, and endocrinology. The cancer segment accounts for the highest market share currently and is expected to remain the leading segment in terms of value during the forecast period.

In terms of route of administration, parenteral route of administration is expected to hold more than half the global market share, while the oral route of administration is projected to expand at the highest CAGR in terms of value.

By drug type, generic drugs are expected to register an exceptional CAGR during the forecast period, owing to patent expiries of large number of branded drugs.

Region-wise, North America is the largest market, and will remain so during the forecast period as well. Markets in the Americas and Europe collectively accounted for over 75% revenue share of the global peptide therapeutics market in 2015.

Send An Enquiry@ www.futuremarketinsights.com/askus/rep-gb-1038

The market in MEA region is projected to exhibit above average CAGR, owing to increase in prevalence of metabolic disorders and increasing number of pharmaceuticals companies in the region.

Key market players covered in this report are AstraZeneca plc, Bachem Holding AG, CordenPharma International GmbH, Eli Lilly and Company, Ipsen S.A, Merck & Co., Inc., Novo Nordisk A/S, PolyPeptide Group and Teva Pharmaceutical Industries Ltd. These players are focusing on enhancing their global and regional presence through strategic mergers & acquisitions through expansion of operations.

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This release was published on openPR.

Transparency Market Research (TMR) has recently published a research study on the global peptide therapeutics market . According to this report, the market is estimated to expand at a moderate CAGR of 2.80% during the period from 2014 to 2020 and reach a value of US$23.7 bn by the end of the forecast period.The research study, titled “Peptide Therapeutics Market – Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 – 2020,” states that the worldwide peptide therapeutics market stood at US$18.9 bn. The rising prevalence of cancer and other diseases is identified as the key factor behind the growth of this market in this research study.

Browse the full Peptide Therapeutics Market (by Applications, by Route of Administration, and by Marketing Status) – Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 – 2020 report at http://www.transparencymarketresearch.com/peptide-therapeutics-market.html

Therapeutic peptides are naturally occurring short amino acid monomer chains, which are beneficial in the treatment of several kinds of cancer, respiratory disorders, cardiovascular disorders, central nervous system (CNS) disorders, blood-related disorders, and other chronic diseases. More than seven thousand organically occurring peptides have been identified till now. Insulin was the first peptide, to be therapeutically administered. Although being used for more than 50 years now, it still enjoys the reputation of the most commonly prescribed peptide.

The research report has studied the global peptide therapeutics market on the basis of application, the route of administration, marketing status, and its regional spread. Based on application, the market is classified into cancer, central nervous system disorders, cardiovascular disorders, gastrointestinal disorders, hematological disorders, respiratory disorders, infections, and acromegaly.

By the route of administration, the report has segmented the peptide therapeutics market into oral administration and parenteral administration and by marketing status, the market has been categorized as branded therapeutic peptides and generic therapeutic peptides.

On the regional front, the worldwide peptide therapeutics market has been classified into Europe, Asia Pacific, North America, and the Rest of the World. In 2014, North America and Europe collectively occupied a share of more than 60% in the overall market.

Asia Pacific, on the other hand, is emerging as the most promising market for peptide therapeutics across the world. Over the forecast period, analysts project Asia Pacific to register the fastest growth among all the regional markets for peptide therapeutics, states the research report.

Japan, China, and India lead the Asia Pacific peptide therapeutics market on account of large pool of patients suffering from cancer and other chronic ailments in these countries. The rapid development in economic condition and the rising awareness pertaining to the treatment of cancer and various other chronic diseases, using therapeutic peptides, are the other prominent factors anticipated to boost the peptide therapeutics market in Asia Pacific, notes the study.

Teva Pharmaceutical Industries Ltd., Takeda Pharmaceutical Co. Ltd., Sanofi, Roche Holdings AG, PolyPeptide Group, Novo Nordisk A/S, Novartis AG, Merck & Co. Inc., Lonza Group Ltd., Ipsen S.A., Eli Lilly and Co., CordenPharma International GmbH, Bachem Holding AG, AstraZeneca Plc, and Amgen Inc. are some of the major companies operating in the global peptide therapeutics market, profiled in this report.

The global peptide therapeutics market is segmented into:

By Application

By Application

Cancer

Zoladex (goserelin)

Velcade (bortezomib)

Lupron/ Enantone/ Eligard (leuprorelin)

Others

Cardiovascular

Angiomax (bivalirudin)

Integrilin (eptifibatide)

Central Nervous System

Copaxone (glatiramer)

Metabolic Disorders

Victoza (liraglutide)

Byetta (exenatide)

Others

Infection

Incivek (telaprevir)

Victrelis (boceprevir)

Hematological Disorders

Firazyr (icatibant)

Kalbitor (ecallantide)

Gastrointestinal Disorders

Gattex (teduglutide)

Linzess (linaclotide)

Respiratory Disorders

Acromegaly

Other Applications

By Route of Administration

Parenteral

Oral

By Marketing Status

Branded

Generic

By Region

North America

Europe

Asia Pacific

Rest of the World

CARY, NC--(Marketwired - February 09, 2017) - The 2nd edition of Industry Standard Research's (ISR's) Small Molecule API Contract Manufacturer Quality Benchmarking report reveals that the top performing CMOs relative to expectations, and based off customer feedback on recent service encounters, are contract manufacturers with a drug innovator as its parent company.
"For the second year in a row, Pfizer CentreOne has been a top performer across all four scorecards," explained Kate Hammeke. "This year, AbbVie Contract Manufacturing placed among the leaders in three of the four scorecards. This is a sign that customers working with embedded CMOs are having their expectations exceeded, but so are respondents who outsource to small and midsize CMOs. Aesica, SAI Life Sciences and Wockhardt received top marks across two scorecards each, which is a sign that regardless of project size or company budget, one can find a CMO whose quality matches your organization's needs."
The report includes information on buyers' outsourcing philosophies and practices, CMO perceptions and interactions, and CMO selection drivers before diving into a series of in-depth performance analyses specific to the small molecule offerings of 36 contract manufacturing organizations. 241 respondents provide rating assessments on 689 service encounters.
The report provides a Consumer Reports-style analysis where each of the 36 CMOs included in the research is evaluated across 27 service quality attributes, making this report the most comprehensive assessment of quality in the contract manufacturing space. These performance metrics are categorized into four 'scorecards': Delivery Factors, Organization Factors, Capabilities and Staff Characteristics. From these performance evaluations, respondents indicated how well the manufacturers performed with respect to expectations specific to their experience working with the manufacturer(s). For buyers of outsourced services, the report includes highly valuable information to help guide CMO selection for small molecule projects from early clinical stages to commercialization.
CMO performance attributes evaluated by respondents include Ability to manufacture small molecule API, Reliable on-time delivery, Regulatory history, Quality performance metrics, Scale-up and tech transfer abilities, Scientific knowledge, Right-first-time measurements, and many others.
Data include an in-depth analysis of 27 of the 36 featured contract manufacturers, including AbbVie Contract Manufacturing, Aesica, Albany Molecular Research Inc. (AMRI), Alcami, Almac, AMPAC Fine Chemicals, Aptuit, Ash Stevens, Cambrex, Dr. Reddy's CPS, Evonik, GSK Contract Manufacturing, Halo Pharma, Lonza, Novasep, Patheon, Pfizer CentreOne, PharmaCore, Piramal Pharma Solutions, Recipharm, SAFC, SAI Life Sciences, Sanofi CEPiA, Siegfried, Wockhardt and Wuxi AppTec.

Creative Peptides has newly released its custom service for accelerating further life sciences research. Progresses in understanding the molecular ...